Efficient microwave assisted syntheses of 2,5-diketopiperazines in aqueous media.
نویسندگان
چکیده
Aqueous in situ one-pot N-Boc-deprotection-cyclization of N alpha-Boc-dipeptidyl-tert-butyl and methyl esters under microwave irradiation afforded 2,5-diketopiperazines (DKPs) in excellent yields. This protocol is rapid, safe, environmentally friendly, and highly efficient, and showed that the tert-butoxy moiety is also an excellent leaving group for these cyclizations.
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ورودعنوان ژورنال:
- Molecules
دوره 14 8 شماره
صفحات -
تاریخ انتشار 2009